慢性腎病貧血藥進展，GSK 更新美國 FDA 新藥審查進度

2024-12-22 21:12:52 | hif

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• 2024-09-14 07:00 HIF-2α- dependent induction of miR-29a restrains T - Nature.com
• 2024-10-21 07:00 Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease - ACS Publications
• 2024-09-24 07:00 A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein - ScienceDirect.com
• 2024-08-28 07:00 Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy - Science
• 2024-09-19 07:00 Latham & Watkins Advises HIF Global on Investment by MOL - Latham & Watkins LLP
• 2024-08-22 07:00 From Bench to Bedside: HIF-2α Inhibition in RCC - OncLive
• 2024-08-06 07:00 Hif-2α programs oxygen chemosensitivity in chromaffin cells - JCI
• 2024-09-20 07:00 MOL Invests in HIF Global, a U.S.-based company of e-Fuels -Toward the Decarbonization of the Mobility Industry with synthetic fuels - - 株式会社商船三井
• 2024-09-03 07:00 Citrullination modulation stabilizes HIF-1α to promote tumour progression - Nature.com
• 2024-09-11 07:00 HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis - Science
• 2024-08-13 07:00 Latham Watkins Advises HIF Global on US36 Million Equity Investment Japan Organization Metals Energy - Latham & Watkins LLP
• 2024-05-16 02:04 HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11 - ScienceDirect.com
• 2024-06-04 07:00 Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α - Nature.com
• 2024-02-27 08:00 The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation - ScienceDirect.com
• 2024-09-19 07:00 The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma - Nature.com
• 2024-04-18 07:00 The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia - Nature.com
• 2024-11-25 08:00 FBP1 over-expression suppresses HIF-1α in papillary thyroid cancer - Nature.com
• 2024-07-24 07:00 HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma - Nature.com
• 2024-05-15 07:00 Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway - Nature.com
• 2024-06-11 07:00 DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer - Nature.com
• 2024-11-23 08:00 Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease - Nature.com
• 2024-06-25 03:45 Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine - Frontiers
• 2024-06-27 07:00 Targeting HIF-1 to treat AML - Nature.com
• 2024-09-15 07:00 NKT-2152: A Promising HIF-2α Inhibitor in ccRCC - Targeted Oncology
• 2024-11-15 08:00 HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells - Nature.com
• 2024-03-12 07:00 The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair | Bone Research - Nature.com
• 2024-05-31 20:06 Stilbenoid derivatives as potent inhibitors of HIF-1α-centric cancer metabolism under hypoxia - ScienceDirect.com
• 2024-10-14 07:00 Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation - Frontiers
• 2024-09-11 12:16 Recombinant canstatin inhibits the progression of hepatocellular carcinoma by repressing the HIF-1α/VEGF signaling pathway - ScienceDirect.com
• 2024-06-05 07:00 HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model - Nature.com
• 2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
• 2024-07-10 07:00 Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia - Nature.com
• 2024-05-02 07:00 NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis - Nature.com
• 2024-05-16 07:00 HIF Global selects Johnson Matthey’s methanol technology for the largest e methanol plant in South America - Johnson Matthey
• 2024-08-23 07:00 LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia - Nature.com
• 2024-11-14 08:00 Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation - Nature.com
• 2024-11-11 08:00 Abstract 4138199: Examining the regulating mechanism of the HIF-FOXM1 axis in promoting adult pig cardiomyocyte proliferation - AHA Journals
• 2024-05-13 07:00 Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner - Nature.com
• 2024-10-04 07:00 MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice - Nature.com
• 2024-07-31 07:00 Monitoring imatinib decreasing pericyte coverage and HIF-1α level in a colorectal cancer model by an ultrahigh-field multiparametric MRI approach - Journal of Translational Medicine
• 2024-05-06 07:00 HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury - Nature.com
• 2024-03-01 08:00 Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer - Nature.com
• 2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
• 2024-11-14 08:00 Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis - Nature.com
• 2024-07-01 07:00 Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ - Nature.com
• 2024-02-15 08:00 PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer - Frontiers
• 2024-05-17 07:54 Exploring the Role of HIF-2α Inhibition in Advanced Clear Cell Renal Cell Carcinoma - ASCO Daily News
• 2024-04-04 07:00 Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation - Nature.com
• 2024-06-27 08:52 The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia - Frontiers
• 2024-06-25 11:04 Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications - Frontiers
• 2024-02-13 08:00 Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin - Nature.com
• 2024-06-26 21:07 Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy - Frontiers
• 2024-03-19 07:00 MOL, Idemitsu, HIF Team up to Develop e-fuel/e-methanol Supply Chain, Including Marine Transport of CO - 株式会社商船三井
• 2024-02-15 23:16 Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha - Frontiers
• 2024-02-16 08:00 HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process - Nature.com
• 2024-01-23 08:00 Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ - ScienceDirect.com
• 2024-02-10 15:52 HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity - ScienceDirect.com
• 2024-07-21 07:00 Relationship between serum iron, zinc, calcium, and HIF-1a—comparative analysis of 2 regions and 4 ethnic groups in China - Frontiers
• 2024-02-16 03:33 Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis - Frontiers
• 2024-02-07 13:42 Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models - Frontiers
• 2024-01-09 08:00 Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation - Nature.com
• 2024-07-14 22:48 The antiangiogenic effect of total saponins of Panax japonicus C.A. Meyer in rheumatoid arthritis is mediated by targeting the HIF-1α/VEGF/ANG-1 axis - ScienceDirect.com
• 2024-02-15 07:14 Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats - Frontiers
• 2024-05-13 07:00 Idemitsu Makes $114 Million Investment in HIF Global to Develop eFuels - FuelCellsWorks
• 2024-01-20 08:00 Linking HIF oxygen-sensing system diversity to hypoxia fitness in Eleutheronema: Molecular characterization and transcriptional response to hypoxia exposure - ScienceDirect.com
• 2021-12-08 04:04 Hydrologic Instrumentation Facility (HIF) - United States Geological Survey
• 2024-07-24 07:00 Airbus signs early-stage deal with green-hydrogen-based e-fuels producer HIF Global - Hydrogen Insight
• 2024-09-23 07:00 Japan's MOL invests e-fuels with HIF Global - Seatrade Maritime News
• 2022-06-20 07:00 The effect of HIF on metabolism and immunity - Nature.com
• 2022-12-06 08:00 HIF Global engages Bechtel, Siemens Energy, and Topsoe for eFuels project in the USA - Bechtel
• 2024-02-05 08:00 Meta-analysis of HIF-PHIs versus ESAs or Placebo in CKD With Anemia - DocWire News
• 2023-08-09 07:00 Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature.com
• 2021-06-07 07:00 A small molecule HIF-1α stabilizer that accelerates diabetic wound healing - Nature.com
• 2017-11-29 05:52 HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia - ScienceDirect.com
• 2024-02-15 08:00 Meta-Analysis: Long-term Safety of HIF-PHIs in Patients With CKD - DocWire News
• 2022-03-03 00:30 RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization - pnas.org
• 2024-09-21 07:00 Hydrogen Economy - MOL invests in HIF Global - HIF Global secured USD 220 million total 2024 equity investments to finance e-Fuels expansion worldwide - Hydrogen Central
• 2021-07-14 07:00 The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling - Nature.com
• 2023-11-23 08:00 Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death - Nature.com
• 2023-10-27 07:00 MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy | Circulation - AHA Journals
• 2019-02-25 08:00 Bidirectional modulation of HIF-2 activity through chemical ligands - Nature.com
• 2024-02-27 08:00 JFE Steel Corporation - jfe-steel.co.jp
• 2021-06-21 07:00 The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes - Nature.com
• 2022-04-28 07:00 Governor Abbott Announces Highly Innovative Fuels Selection Of Matagorda County For eFuels Facility In Bay City - Office of the Texas Governor
• 2022-03-05 03:12 Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity - pnas.org
• 2023-05-24 07:00 Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy - Nature.com
• 2021-09-16 05:52 Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling - Science
• 2021-08-18 07:00 HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19 - Nature.com
• 2017-12-12 04:19 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption - ScienceDirect.com
• 2020-06-25 07:00 Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy - Nature.com
• 2021-09-17 22:25 Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch - Science
• 2014-10-09 07:00 Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation - ScienceDirect.com
• 2022-10-08 07:00 HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis | Cell Death & Disease - Nature.com
• 2016-01-13 08:00 Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis - Nature.com
• 2021-09-28 07:00 HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells - ScienceDirect.com
• 2019-01-16 08:00 HIF-1α metabolically controls collagen synthesis and modification in chondrocytes - Nature.com
• 2022-09-05 07:00 HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection - Nature.com
• 2021-06-21 07:00 Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy | Oncogene - Nature.com
• 2018-10-26 07:00 Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance - Nature.com
• 2023-08-29 07:00 14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer - ScienceDirect.com

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hif, 慢性腎病貧血藥進展，GSK 更新美國 FDA 新藥審查進度 2022 hif

慢性腎病貧血藥進展，GSK 更新美國 FDA 新藥審查進度

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